Blar i Bergen Open Research Archive på forfatter "Nielsen, Rune"
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Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma
Gagnat, Ane Aamli; Gjerdevik, Miriam; Lie, Stein Atle; Gulsvik, Amund; Bakke, Per S.; Nielsen, Rune (Journal article; Peer reviewed, 2020)Rationale There is limited knowledge on the effect of acute exacerbations in chronic obstructive pulmonary disease (AECOPD) on lung cancer risk in COPD patients with and without a history of asthma. This study aims to ... -
Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study
Ratanachina, Jate; Amaral, Andre F.S.; De Matteis, Sara; Lawin, Herve; Mortimer, Kevin; Obaseki, Daniel O.; Harrabi, Imed; Denguezli, Meriam; Wouters, Emiel F.M.; Janson, Christer; Nielsen, Rune; Gulsvik, Amund; Cherkaski, Hamid Hacene; Mejza, Filip; Mahesh, Padukudru Anand; Elsony, Asma; Ahmed, Rana; Tan, Wan C.; Loh, Li Cher; Rashid, Abdul; Studnicka, Michael; Nafees, Asaad A.; Seemungal, Terence; Aquart-Stewart, Althea; Al Ghobain, Mohammed; Zheng, Jinping; Juvekar, Sanjay; Salvi, Sundeep; Jogi, Rain; Mannino, David M.; Gislason, Thorarinn; Buist, A. Sonia; Cullinan, Paul; Burney, Peter G.J.; Hafizi, Hasan; Aliko, Anila; Bardhi, Donika; Tafa, Holta; Thanasi, Natasha; Mezini, Arian; Teferici, Alma; Todri, Dafina; Nikolla, Jolanda; Kazasi, Rezarta; Bengrait, Amira; Haddad, Tabarek; Zgaoula, Ibtissem; Ghit, Maamar; Roubhia, Abdelhamid; Boudra, Soumaya; Atoui, Feryal; Yakoubi, Randa; Benali, Rachid; Bencheikh, Abdelghani; Ait-Khaled, Nadia; Jenkins, Christine; Marks, Guy; Bird, Tessa; Espinel, Paola; Hardaker, Kate; Toelle, Brett; Dawes, Torkil; Lamprecht, Bernd; Schirhofer, Lea; Islam, Akramul; Ahmed, Syed Masud; Islam, Shayla; Islam, Qazi Shafayetul; Mesbah-Ul-Haque, NN; Chowdhury, Tridib Roy; Chatterjee, Sukantha Kumar; Mia, Dulal; Das, Shyamal Chandra; Rahman, Mizanur; Islam, Nazrul; Uddin, Shahaz; Islam, Nurul; Khatun, Luiza; Parvin, Monira; Khan, Abdul Awal; Islam, Maidul; Kpangon, Arsene; Kpossou, Karl; Agodokpessi, Gildas; Ayelo, Paul; Fayomi, Benjamin; Mbatchou, Bertrand; Ashu, Atongno Humphrey; Wang, Wen; Zhong, NanShan; Liu, Shengming; Lu, Jiachun; Ran, Pixin; Wang, Dali; Zhou, Yumin; Laja, Hendrik; Ulst, Katrin; Zobel, Vappu; Lill, Toomas-Julius; Adegnika, Ayola Akim; Welte, Tobias; Bodemann, Isabelle; Geldmacher, Henning; Schweda-Linow, Alexandra; Benedikdtsdottir, Bryndis; Jörundsdottir, Kristin; Gudmundsdottir, Lovisa; Gudmundsdottir, Sigrun; Gundmundsson, Gunnar; Koul, Parvaiz A.; Malik, Sajjad; Hakim, Nissar A.; Khan, Umar Hafiz; Chowgule, Rohini; Shetye, Vasant; Raphael, Jonelle; Almeda, Rosel; Tawde, Mahesh; Tadvi, Rafiq; Katkar, Sunil; Kadam, Milind; Dhanawade, Rupesh; Ghurup, Umesh; Hirve, Siddhi; Sambhudas, Somnath; Chaidhary, Bharat; Tambe, Meera; Pingale, Savita; Umap, Arati; Umap, Archana; Shelar, Nitin; Devchakke, Sampada; Chaudhary, Sharda; Bondre, Suvarna; Walke, Savita; Gawhane, Ashleshsa; Sapkal, Anil; Argade, Rupali; Gaikwad, Vijay; Brashier, Sundeep Bill; Londhe, Jyoti; Madas, Sapna; Aikman, Althea Akosua Francia; Sooronbaev, Talant M.; Estebesova, Bermet M.; Akmatalieva, Meerim; Usenbaeva, Saadat; Kydyrova, Jypara; Bostonova, Eliza; Sheraliev, Ulan; Marajapov, Nuridin; Toktogulova, Nurgul; Emilov, Berik; Azilova, Toktogul; Beishekeeva, Gulnara; Dononbaeva, Nasyikat; Tabyshova, Aijamal; Mwangoka, Ernest; Kambwili, Mayamiko; Chipeta, Martha; Banda, Gloria; Mkandawire, Suzgo; Banda, Justice; Sholehah, Siti; Benjelloun, Mohamed C.; Nejjari, Chakib; Elbiaze, Mohamed; El Rhazi, Karima; Franssen, F.F.E.; Wesseling, G.J.; Erhabor, Gregory; Awopeju, Olayemi; Adewole, Olufemi; Endresen, Tina; Svendsen, Lene Løvendahl; Irfan, Muhammad; Fatmi, Zafar; Zahidie, Aysha; Shaukat, Natasha; Iqbal, Meesha; Idolor, Luisito F.; de Guia, Teresita S.; Francisco, Norberto A.; Roa, Camilo C.; Ayuyao, Fernando G.; Tady, Cecil Z.; Tan, Daniel T.; Banal-Yang, Sylvia; Balanag, Vincent M.; Reyes, Maria Teresita N.; Dantes, Renato B.; Amarillo, Lourdes; Berratio, Lakan U.; Fernandez, Lenora C.; Garcia, Gerard S.; Naval, Sullian S.; Reyes, Thessa; Roa, Camilo C.; Sanchez, Ma. Flordeliza; Simpao, Leander P.; Nizankowska-Mogilnicka, Ewa; Frey, Jakub; Harat, Rafal; Nastalek, Pawel; Pajak, Andrzej; Skucha, Wojciech; Szczeklik, Andrzej; Twardowska, Magda; Bárbara, Cristina; Rodrigues, Fátima; Dias, Hermínia; Cardoso, João; Almeida, João; Matos, Maria João; Simão, Paula; Santos, Moutinho; Ferreira, Reis; Alorainy, H.; El-Hamad, E.; Al Hajjaj, Hajjaj; Hashi, A.; Dela, R.; Fanuncio, R.; Doloriel, E.; Marciano, I.; Safia, L.; Bateman, Eric; Jithoo, Anamika; Adams, Desiree; Barnes, Edward; Freeman, Jasper; Hayes, Anton; Hlengwa, Sipho; Johannisen, Christine; Koopman, Mariana; Louw, Innocentia; Ludick, Ina; Olckers, Alta; Ryck, Johanna; Storbeck, Janita; Gunasekera, Kirthi; Wickremasinghe, Rajitha; Elsadig, Hana A.; Osman, Nada Bakery; Noory, Bandar Salah; Mohamed, Monjda Awad; Osman, Hasab Alrasoul Akasha Ahmed; ed Elhassan, Namarig Moham; El Zain, Abdel Mu'is; Mohamaden, Marwa Mohamed; Khalifa, Suhaiba; Elhadi, Mahmoud; Hassan, Mohand; Abdelmonam, Dalia; Kamal, Rashid; Eltigani, Hind; Umar, Stephen's; Abdeen, Aya; Osman, Mihad; Mohamed, Malaz; Eltayeb, Roa; Abelazeez, Mohamed; Altaher, Hoyam; Mohamed, Lina; Abdarahman, Rabee; Mohamed, Rayan; Haram, NN; Ismaeel, Rimaz; Olafsdottir, Inga Sif; Nisser, Katarina; Spetz-Nyström, Ulrike; Hägg, Gunilla; Lund, Gun-Marie; Lutchmansingh, Fallon; Conyette, Liane; Tabka, Zouhair; Daldoul, Hager; Boukheroufa, Zaki; Chouikha, Firas; Khalifa, Wahbi Belhaj; Kocabaş, Ali; Hancioglu, Attila; Hanta, Ismail; Kuleci, Sedat; Turkyilmaz, Ahmet Sinan; Umut, Sema; Unalan, Turgay; Gnatiuc, Louisa; Azar, Hadia; Patel, Jaymini; Amor, Caron; Potts, James; Tumilty, Michael; McLean, Fiona; Dudhaiya, Risha; McBurnie, Mary Ann; Vollmer, William M.; Gillespie, Suzanne; Sullivan, Sean; Lee, Todd A.; Weiss, Kevin B.; Jensen, Robert L.; Crapo, Robert; Enright, Paul; Cain, John; Copeland, Rebecca; Hazen, Dana; Methvin, Jennifer (Journal article; Peer reviewed, 2023)Background Chronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive ... -
Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status
Nerpin, Elisabet; Ferreira, Diogenes Seraphim; Weyler, Joost; Schlunnsen, Vivi; Jogi, Rain; Raherison, Chantal; Gislasson, Thorainn; Demoly, Pascal; Heinrich, Joachim; Nowak, Dennis; Corsico, Angelo; Accordini, Simone; Marcon, Alessandro; Squillacioti, Giulia; Olivieri, Mario; Nielsen, Rune; Johannessen, Ane; Real, Francisco Gomez; Garcia-Aymerich, Judith; Urrutia, Isabel; Pereira-Vega, Antonio; Gullón, José-Antonio; Olin, Anna-Carin; Forsberg, Bertil; Emilsson, Össur Ingi; Pin, Isabelle; Jarvis, Deborah; Janson, Christer; Malinovschi, Andrei (Journal article; Peer reviewed, 2021)Background Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients. The associations of FeNO with lung function decline and ... -
Chronic airflow obstruction and ambient particulate air pollution
Amaral, André F.S.; Burney, Peter G.J.; Patel, Jaymini; Minelli, Cosetta; Mejza, F; Mannino, David M.; Seemungal, Terence A.R.; Mahesh, Padukudru Anand; Lo, Li Cher; Janson, Christer; Juvekar, Sanjay; Denguezli, Meriam; Harrabi, Imed; Wouters, Emiel F.M.; Cherkaski, Hamid; Mortimer, Kevin; Jogi, Rain; Bateman, Eric D.; Fuertes, Elaine; Al Ghobain, Mohammed; Tan, Wan; Obaseki, Daniel O.; El Sony, Asma; Studnicka, Michael; Aquart-Stewart, Althea; Koul, Parvaiz; Lawin, Herve; Nafees, Asaad Ahmed; Awopeju, Olayemi; Erhabor, Gregory E.; Gislason, Thorarinn; Welte, Tobias; Gulsvik, Amund; Nielsen, Rune; Gnatiuc, Louisa; Kocabas, Ali; Marks, Guy B.; Sooronbaev, Talant; Ngahane, Bertrand Hugo Mbatchou; Barbara, Cristina; Sonia Buist, Buist (Journal article; Peer reviewed, 2021)Smoking is the most well-established cause of chronic airflow obstruction (CAO) but particulate air pollution and poverty have also been implicated. We regressed sex-specific prevalence of CAO from 41 Burden of Obstructive ... -
Complications and discomfort after research bronchoscopy in the MicroCOPD study
Leiten, Elise Orvedal; Eagan, Tomas Mikal; Martinsen, Einar Marius Hjellestad; Nordeide, Eli; Husebø, Gunnar; Knudsen, Kristel Svalland; Lehmann, Sverre; Svanes, Øistein; Bakke, Per S.; Nielsen, Rune (Journal article; Peer reviewed, 2020)Background: Data on discomfort and complications from research bronchoscopy in chronic obstructive pulmonary disease (COPD) and asthma is limited. We present complications and discomfort occurring within a week after ... -
Cost effectiveness of adding budesonide/formoterol to tiotropium in COPD in four Nordic countries
Nielsen, Rune; Kankaanranta, Hannu; Bjermer, Leif; Lange, Peter; Arnetorp, Sofie; Hedegaard, Morten; Stenling, Anna; Mittmann, Nicole (Peer reviewed; Journal article, 2013-11)Objective: Assess the cost effectiveness of budesonide/formoterol (BUD/FORM) Turbuhaler®+tiotropium (TIO) HandiHaler® vs. placebo (PBO)+TIO in patients with chronic obstructive pulmonary disease (COPD) eligible for inhaled ... -
Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III
Nerpin, Elisabet; Olivieri, Mario; Gislason, Thorainn; Olin, Anna C.; Nielsen, Rune; Johannessen, Ane; Ferreira, Diogenes S.; Marcon, Alessandro; Cazzoletti, Lucia; Accordini, Simone; Pin, Isabelle; Corsico, Angelo; Demoly, Pascal; Weyler, Joost; Nowak, Dennis; Jõgi, Rain; Forsberg, Bertil; Zock, Jan P.; Sigsgaard, Torben; Heinric, Joachim; Bono, Roberto; Leynaert, Bénédicte; Jarvis, Deborah; Janson, Christer; Malinovschi, Anderi (Peer reviewed; Journal article, 2019)Introduction: The fractional exhaled nitric oxide (FENO ) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors ... -
Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4
Drengenes, Christine; Eagan, Tomas Mikal; Haaland, Ingvild; Wiker, Harald G; Nielsen, Rune (Journal article; Peer reviewed, 2021)Background Studies on the airway microbiome have been performed using a wide range of laboratory protocols for high-throughput sequencing of the bacterial 16S ribosomal RNA (16S rRNA) gene. We sought to determine the ... -
Factors associated with coronary heart disease in COPD patients and controls
Svendsen, Christina D.; Kuiper, Karel Kier-Jan; Ostridge, Kristoffer; Larsen, Terje Hjalmar; Nielsen, Rune; Hodneland, Vidar; Nordeide, Eli; Bakke, Per S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022-04-27)Background: COPD and coronary heart disease (CHD) frequently co-occur, yet which COPD phenotypes are most prone to CHD is poorly understood. The aim of this study was to see whether COPD patients did have a true higher ... -
Incremental costs of COPD exacerbations in GOLD stage 2+ COPD in ever-smokers of a general population
Erdal, Marta; Johannessen, Ane; Bakke, Per S.; Gulsvik, Amund; Eagan, Tomas Mikal; Nielsen, Rune (Journal article; Peer reviewed, 2020-11)Objectives To estimate treatment- and productivity-related costs associated with COPD in two different samples, and to analyse the association between the costs and moderate and severe exacerbations. Methods We performed ... -
Laboratory contamination in airway microbiome studies
Drengenes, Christine; Wiker, Harald G; Kalananthan, Tharmini; Nordeide, Eli; Eagan, Tomas Mikal; Nielsen, Rune (Peer reviewed; Journal article, 2019-08-14)Background The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have ... -
A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease
Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Wiker, Harald Gotten; Leiten, Elise Orvedal; Husebø, Gunnar Reksten; Knudsen, Kristel Svalland; Tangedal, Solveig; Sanseverino, Walter; Paytuví-Gallart, Andreu; Nielsen, Rune (Journal article; Peer reviewed, 2022-05-12)Background: Few studies have examined the stability of the pulmonary mycobiome. We report longitudinal changes in the oral and pulmonary mycobiome of participants with and without COPD in a large-scale bronchoscopy study ... -
The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease
Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune; Tangedal, Solveig; Haaland, Ingvild; Hiemstra, Pieter S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022)Background The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and ... -
The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis
Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune; Tangedal, Solveig; Paytuví-Gallart, Andreu; Sanseverino, Walter; Martinsen, Einar Marius Hjellestad; Hiemstra, Pieter S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022-10-19)Background: The role of the pulmonary microbiome in sarcoidosis is unknown. The objectives of this study were the following: (1) examine whether the pulmonary fungal and bacterial microbiota differed in patients with ... -
Motivation and response rates in bronchoscopy studies
Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal; Leiten, Elise Orvedal; Nordeide, Eli; Bakke, Per S.; Lehmann, Sverre; Nielsen, Rune (Peer reviewed; Journal article, 2019-05-02)Background Bronchoscopy is frequently used to sample the lower airways in lung microbiome studies. Despite being a safe procedure, it is associated with discomfort that may result in reservations regarding participation ... -
Period and cohort effects: consequences on spirometric lung function in Norway during the 20th century
Cestelli, Lucia; Johannessen, Ane; Stavem, Knut; Gulsvik, Amund; Nielsen, Rune (Journal article; Peer reviewed, 2022)Background and aim Several factors can influence measured lung function over time. The aim of this study was to investigate period and cohort effects on spirometric measures in a large general population sample in Norway ... -
Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III
Janson, Christer; Accordini, Simone; Cazzoletti, Lucia; Cerveri, Isa; Chanoine, S; Corsico, Angelo; Ferreira, D.S.; Garcia-Aymerich, Judith; Gislason, Thorarinn; Nielsen, Rune; Johannessen, Ane; Jõgi, Rain; Malinovschi, Andrei; Moratalla, Jesús Martínez; Marcon, Alessandro; Pin, Isabelle; Quint, JK; Siroux, Valerie; Almar, Enrique; Bellisario, Valeria; Franklin, Karl A.; Gullon, JA; Holm, Mathias; Heinrich, Joachim; Nowak, Dennis; Sánchez-Ramos, José Luis; Weyler, Joost; Jarvis, Deborah (Peer reviewed; Journal article, 2019)Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with ... -
The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease
Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Leiten, Elise Orvedal; Haaland, Ingvild; Husebø, Gunnar Reksten; Knudsen, Kristel Svalland; Drengenes, Christine; Sanseverino, Walter; Paytuví-Gallart, Andreu; Nielsen, Rune (Journal article; Peer reviewed, 2021-04-07)Background: The fungal part of the pulmonary microbiome (mycobiome) is understudied. We report the composition of the oral and pulmonary mycobiome in participants with COPD compared to controls in a large-scale single-centre ... -
Repeated bronchoscopy in health and obstructive lung disease: is the airway microbiome stable?
Nielsen, Rune; Xue, Yaxin; Jonassen, Inge; Haaland, Ingvild; Kommedal, Øyvind; Wiker, Harald Gotten; Drengenes, Christine; Bakke, Per S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2021)Objective Little is known concerning the stability of the lower airway microbiome. We have compared the microbiota identified by repeated bronchoscopy in healthy subjects and patients with ostructive lung diseaseases ... -
Respiratory symptoms and mortality in four general population cohorts over 45 years
Gulsvik, Amund; Bakke, Per; Brøgger, Jan; Nielsen, Rune; Stavem, Knut (Journal article; Peer reviewed, 2020)Objective: This study assessed the association between respiratory symptoms and mortality in four cohorts of the general population in Norway aged 15–75 years and in selected subgroups in the pooled sample. Methods: The ...